Three-Component Assembly of Conjugated Enyne Scaffolds via <i>E</i>-Selective Olefination of Ynals

Abstract

Benefited by the accessible ynamido–lithium intermediates <b>Ib</b> from a Cu-catalyzed azide–alkyne cycloaddition in the presence of stoichiometric amounts of LiOH, a mild and flexible three-component route to conjugated enyne scaffolds was successfully achieved via a formal <i>E</i>-selective olefination strategy

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