Top age at onset (AAO) meta-analysis results for the <i>FOXO1</i> region.

Abstract

1<p>Position for genome build 36.3 (hg18).</p>2<p>Required p-value level for significance p-values = 8.68E-5; <b>bold</b> indicates significant p-value.</p>3<p>Direction of effects are listed in the following order: PROGENI/GenePD, NIA Phase I, NIA Phase II, LEAPS, HIHG, NGRC; a question mark (?) indicates that the marker failed imputation (Rsq<0.30).</p>4<p>Values for imputed (I) or genotyped (G) status.</p>5<p>The meta-analysis included the PROGENI/GenePD, NIA Phase I, NIA Phase II, HIHG, and NGRC studies.</p>6<p>The SNPExpress database <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1002794#pgen.1002794-Heinzen1" target="_blank">[29]</a> was used to look up eSNP relationships between the expression of <i>FOXO1</i> transcripts or exons and the SNPs of interest. The best <i>FOXO1</i> eSNP result is displayed if a p-value<0.05 was observed. The presented eSNP results were obtained in brain tissue. N/A values are used when the SNPs were not available in the database.</p