DBoMM can catch the conditional dependent interactions and distinguish the real gene interactions from the background.

Abstract

<p>The expression profiles of two interacting genes (a) and non-interacting genes (c) are fitted into a bivariate mixture Gaussian distribution (joint distribution with different colors). The expression profiles of two interacting genes (b) and non-interacting genes (d) are separately fitted into two univariate mixture Gaussian distribution (marginal distribution). The blue and green lines represent the distribution of the two genes respectively. The contours correspond to the joint densities implied by DBoMM.</p