Cu(II)-Promoted Transformations of α-Thienylcarbinols into Spirothienooxindoles: Regioselective Halogenation of Dienyl Sulfethers Containing Electron-Rich Aryl Rings

Abstract

Under the promotion of Cu­(II) salts, the α-thienylcarbinols with an <i>N</i>-phenyl carbonyl group at the other α-position are converted into three different ranges of spirothienooxindoles involving dearomatizing Friedel–Crafts reaction. In addition, the unprecedented regioselective CuX₂-mediated C–H functionalization/halogenation of dienyl sulfether containing electron-rich aryl rings is presented