A catalogue of mixed feed-forward regulatory loops (FFLs).

Abstract

<p>According to the relationship between the transcription factor (TF) and microRNA (miRNA), the mixed FFLs were classified as the TF-FFL model (the TF directly regulates the miRNA), miRNA-FFL model (the miRNA only directly regulates the TF) or composite-FFL model (the TF and the miRNA regulate each other). The relationships represented by solid lines are required while the relationships represented by dot lines are not required. B) Five types of putative regulations involved in these FFLs: miRNA-gene represents that the miRNA represses gene expression; miRNA-TF represents that the miRNA represses the TF gene expression; TF-gene represents the regulation by TF of the expression of the gene; TF-miRNA represents the regulation of TF to expression of miRNAs; and, gene-gene represents gene coexpression.</p

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