Pyrimidine metabolism in tumour versus normal and at acquired resistance.

Abstract

<p>Genes involved in pathways of DNA metabolism and production in tumour versus normal (red corresponds to overexpressed and dark green correspond to down-regulated) and in acquired resistant tumour (in ovals, all were overexpressed). Abbreviations: 2.1.3.2 =  aspartate transcarbamylase 3.5.2.3 =  dihydroorotase 6.3.5.5 =  CAD; carbamoyl-phosphate synthetase 2 3.1.3.5 =  NT5C; 5′-nucleotidase 2.7.7.7 =  POLA2; DNA polymerase alpha subunit B 2.7.7.7 =  POLD1; DNA polymerase delta subunit 1 1.17.4.1 =  RRM2B; ribonucleoside-diphosphate reductase subunit M2 2.4.2.4 =  TYMP; thymidine phosphorylase.</p