Impaired maturation of a subset of miRNAs in <i>Dicer^d/d</i> mutant splenocytes and macrophages.

Abstract

<p>A. Scatterplot showing relative expression of miRNAs by macroarray. In red, are shown miRNAs up-regulated in naïve (NI) splenocytes from <i>Dicer^d/d</i> mutants and green depicts down-regulated miRNAs. B. Scatterplot obtained upon macroarray analysis of mRNA extracted from control (+/+) and <i>Dicer^d/d</i> non-infected macrophages. C. Repartition of miRNAs down-regulated (green) or with similar expression (blue) in mutant splenocytes and macrophages. D. qRT-PCR experiments on selected miRNAs were performed on miRNA isolated from control (+/+, dark bars) and <i>Dicer^d/d</i> mutant (white bars) spleens.</p