<p><b>A.</b> Retinal histology from 1-year-old mice of the genotypes indicated. Note that the retinal structure of the N-SF-TAP-<i>Rp1</i> line T1 and N-LAP-<i>Rp1</i> lines L1 and L2 is normal. In contrast, there is photoreceptor degeneration evident in N-SF-TAP-<i>Rp1</i> lines T2 and T3, and N-LAP-<i>Rp1</i> line L3, with loss of photoreceptor nuclei and shortening of photoreceptor outer segments. (INL, inner nuclear layer; IS, inner segment; ONL, outer nuclear layer; OS, outer segment; 400× magnification for all images). <b>B.</b> Ultrastructure of photoreceptor sensory cilia in one-year old N-SF-TAP-<i>Rp1</i> line T1 and N-LAP-<i>Rp1</i> line L2 mice, compared to that of wild-type littermate control. Note that the structure of the PSC and organization of the outer segment discs are normal in both transgenic lines, consistent with the histology shown in A. <b>C.</b> Amplitudes of ERG responses from 1-year-old N-SF-TAP-<i>Rp1</i> line T1 and N-LAP-<i>Rp1</i> line L2 mice, compared to that of wild-type littermate controls. Note that the rod and cone ERG amplitudes are normal in both lines of transgenic mice.</p
