Expression of selected genes in gastrocnemius muscle.
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Abstract
<p>Mice were killed either without any additional manipulations, that is, while offered various ‘original’ cHF-based diets (<b>OrD</b>; crossed bars), or following the diet-switch protocol when re-fed Chow diet (full bars); see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0043764#pone-0043764-g001" target="_blank">Fig. 1</a>. <b>A</b>.Genes involved in carbohydrate metabolism: pyruvate dehydrogenase kinase isozyme 4 (<i>Pdk4</i>); fructose-1,6-bisphosphatase isoenzyme 2 (<i>Fbp2</i>); and glucose transporter type 4 (<i>Glut4</i>). <b>B</b>. Genes involved in lipid metabolism: acyl-CoA thioesterase 1 (<i>Acot1</i>); carnitine palmitoyltransferase 1b (<i>Cpt1b</i>); and CD36 antigen (<i>Cd36</i>). <b>C</b>. Slow muscle (oxidative) fiber genes: myosin, heavy polypeptide 6 (<i>Myh6</i>); myosin, heavy polypeptide 7 (<i>Myh7</i>); and troponin C type 1 (<i>Tnnc1</i>). <b>D. </b><i>Pgc1α</i>. <b>E.</b> Cytochrome P450, family 1, subfamily a, polypeptide 1 (<i>Cyp1a1</i>). Data are means±SE (<i>n</i> = 7–8). See also <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0043764#pone.0043764.s007" target="_blank">Table S6</a>. <sup>a</sup>Significantly different from cHF, OrD; <sup>b</sup>significantly different from cHF+F, OrD; <sup>c</sup>significantly different from cHF+ROSI, OrD; <sup>d</sup>significantly different from cHF+F+ROSI, OrD; <sup>e</sup>significantly different from cHF+F+ROSI, re-fed Chow (ANOVA).</p