Rates of activation for Kv11.1 channels at 0 mV.

Abstract

<p>A. Typical examples of Kv11.1-3.1 currents recorded at 37°C during an envelope-of-tails voltage clamp protocol to measure rates of activation at 0 mV. The voltage protocol is shown at the top of the panel. The dashed line highlights the peak tail current for each current trace. B. Normalized peak tail current plotted against duration of the test pulse for Kv11.1-1A (○) and Kv11.1-3.1 (•). The inset shows the mean ± SEM for time constants of activation (n = 4−5). τ<sub>act, 0 mV</sub> for Kv11.1-1A (58±5 ms, n = 5) was not significantly larger than that for Kv11.1-3.1 (57±5 ms, n = 4).</p

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