Action potential simulation for Kv11.1-A and Kv11.1-3.1.

Abstract

<p>Typical current responses for the 1<sup>st</sup>, 5<sup>th</sup> and 61<sup>st</sup> pulse for A. Kv11.1-1A and B. Kv11.1-3.1 during a pulse protocol where cells were repetitively depolarized to +40 mV for 5 ms, from a holding potential of <b>−</b>70 mV with interpulse interval of 15 ms (voltage protocol shown at top of panel). Currents were measured at 1 ms (red dashed line) and 3 ms (blue dashed line) and the values normalized to the peak tail current recorded for each cell at <b>−</b>120 mV after a 1 s step to +40 mV to fully activate the channels (data not shown). C. Normalized currents measured at 1 ms (red symbols) plotted against time for Kv11.1-1A (○), Kv11.1-1A/Kv11.1-3.1 (*) and Kv11.1-3.1 (•) with the 1<sup>st</sup>, 5<sup>th</sup> and 61<sup>st</sup> pulse highlighted by the black arrows. D. Normalized currents measured at 3 ms (blue symbols) plotted against time for Kv11.1-1A (○) and Kv11.1-3.1 (•). 1<sup>st</sup>, 5<sup>th</sup> and 61<sup>th</sup> pulse highlighted with black arrows. The data for the Kv11.1-1A/Kv11.1-3.1 channels has been left out of panel D for purposes of clarity (due to overlapping error bars). Panel C and D only show every second data point for purposes of clarity.</p

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