Epigenetic signatures correlate with gene expression patterns.

Abstract

<p>(<b>A</b>) H3K4me2 and H3K27 accumulation in examples of genes specifically expressed in other non-retinal tissues. (<b>B</b>) Percentage of the genes lacking both H3K4me2 and H3K27me3 accumulation (18%, 4,527 genes) at TSS regions (+/−2.5 Kb) through all developmental stages from all RefSeq genes (totally 20,626 genes) tested by an analysis of Euclidean raw distances (see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0046867#pone.0046867.s018" target="_blank">Text S1</a>). (<b>C</b>) Categorizes genes (4.527 genes in <b>c</b>) lacking both H3K4me2 and H3K27me3 accumulation at TSS by their biological function and tissue specificity. Top 10 categories of genes are listed and “others” (48%) are genes with GO annotations and not listed in the pie chart; “unknown” (19%) are genes without GO annotations and not listed in the pie chart (see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0046867#pone.0046867.s004" target="_blank">Table S2</a>). (<b>D</b>) H3K4me2 and H3K27 accumulation in examples of genes ubiquitously expressed in most tissues. Y-axis represents the number of reads in a 100 bp interval.</p