<p>(A) Schematic view of location and sequences of transcription factor binding sites in NOCE. Red characters indicate exchanged nucleotides of mutated sites. (B) Transactivation of wild type and mutated NOCE constructs. Arabical numbers indicate different mutated binding sites: (1) FOXA2, (2) TCF/LEF, (3) TEAD. Cotransfected constructs of transcription factors are indicated below. (C) β-galactosidase staining of chimeric embryos carrying promoter-reporter transgenes with mutated FOXA2, TEAD and TCF/LEF binding sites (NOCE 3x mut) and an additional mutation in the HOX binding site (in NOCE 4x mut) in NOCE.</p
