Circulating DNA content, MPO activity and NETs formation in healthy subjects and SIRS patients.
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Abstract
<p>(<b>A</b>) DNA content in the plasma of SIRS patients and control samples (***p<0.001 vs control). (<b>B</b>) MPO activity in plasma of SIRS patients and control subjects (***p<0.001 vs control). (<b>C</b>) MPO activity in PMNs of SIRS patients and control subject. (<b>D</b>) PCR of mitochondrial genes [ATP synthase subunit 6 (atp6), cytochrome oxidase c subunit 1 (co1)], and (<b>E</b>) nuclear genes [Glyceraldehyde-3-phosphate dehydrogenase (gapdh), and β-actin]. (<b>F</b>) Bar diagram representing NETs formation in neutrophils from healthy subjects and SIRS patients following PMA treatment (*p<0.05, ***p<0.001 vs control; <sup></sup>p<0.01,<sup>$</sup>p<0.001 vs PMA stimulated cells of healthy volunteer).</p