Abstract

<p>HRs were calculated in models stratified by study that used age as the underlying time scale. Multivariable models were adjusted for gender, alcohol consumption (0, 0.1–14.9, 15.0–29.9, 30.0+ g/d), education (did not complete high school, completed high school, post-high-school training, some college, completed college), marital status (married, divorced, widowed, unmarried), history of heart disease, history of cancer, BMI (<18.5, 18.5–19.9, 20–22.4, 22.5–24.9, 25–27.4, 27.5–29.9, 30+ kg/m<sup>2</sup>), and smoking status (never, former, current). If a covariate was a stratification variable for a particular model, then it was excluded from multivariable adjustment. Years of life expectancy gained after age 40 were derived using direct adjusted survival curves <a href="http://www.plosmedicine.org/article/info:doi/10.1371/journal.pmed.1001335#pmed.1001335-Ghali1" target="_blank">[31]</a>,<a href="http://www.plosmedicine.org/article/info:doi/10.1371/journal.pmed.1001335#pmed.1001335-Makuch1" target="_blank">[32]</a> for participants who were 40+ y of age at baseline (97.5% of participants).</p>a<p>Years of life expectancy gained after age 60. Cancer and/or heart disease were uncommon prior to this age in our dataset.</p>b<p>Participants who had never smoked and who had no history of heart disease or cancer.</p

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