Three is-ncRNAs contributing to UV resistance.

Abstract

<p>Candidate ncRNAs were knocked down by RNAi via feeding in wild-type worms. A, L4 larval survival following UV irradiation. Worms of L4 stage larvae were exposed to UV irradiation (0, 50, 100, 150, or 200 J/m<sup>2</sup>). Worm survival was determined about 24 h after UV treatment. Each point represents the mean of three independent experiments, each performed in duplicate (typically, n>60). Error bars denote the SEM. B, Effects of target is-ncRNAs knockdown on UV-DDR-related genes. Quantitative RT-PCR was used to detect the relative expression level of UV-DDR-related genes in RNAi-treated adult worms. Error bars show the mean ± SEM of at least three independent experiments. *: p<0.05, **: p<0.01, ***: p<0.001.</p

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