Abstract

<p>The points shown represent the HR (A) or years of life gained (B) for each of the physical activity categories examined, and the vertical lines represent the 95% CIs for that physical activity category. The reference category for both (A) and (B) is 0.0 MET-h/wk of leisure time physical activity. The lines connecting the points help to illustrate the dose–response relationship between physical activity and risk of mortality; the shape of the association shown here is similar to that obtained using spline modeling (<a href="http://www.plosmedicine.org/article/info:doi/10.1371/journal.pmed.1001335#pmed.1001335.s001" target="_blank">Figure S1</a>). HRs were calculated in models stratified by study that used age as the underlying time scale. Multivariable models were adjusted for gender, alcohol consumption (0, 0.1–14.9, 15.0–29.9, 30.0+ g/d), education (did not complete high school, completed high school, post-high-school training, some college, completed college), marital status (married, divorced, widowed, unmarried), history of heart disease, history of cancer, BMI (<18.5, 18.5–19.9, 20–22.4, 22.5–24.9, 25–27.4, 27.5–29.9, 30+ kg/m<sup>2</sup>), and smoking status (never, former, current). Years of life expectancy gained after age 40 were derived using direct adjusted survival curves <a href="http://www.plosmedicine.org/article/info:doi/10.1371/journal.pmed.1001335#pmed.1001335-Ghali1" target="_blank">[31]</a>,<a href="http://www.plosmedicine.org/article/info:doi/10.1371/journal.pmed.1001335#pmed.1001335-Makuch1" target="_blank">[32]</a> for participants who were 40+ y of age at baseline (97.5% of participants).</p

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