Investigating the Effects
of a Hydrolytically Stable
Hapten and a Th1 Adjuvant on Heroin Vaccine Performance
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Abstract
We challenged the performance of our previous heroin
vaccine with
a similar vaccine containing a more hydrolytically stable hapten analogue
and a Th1 adjuvant (CpG ODN). Our results indicate that the elements
of our previous vaccine are essential for its anti-heroin potency,
i.e., a chemically labile hapten and an exclusively Th2 humoral response
elicited by alum. Such design elements are critical for producing
next-generation heroin vaccines