HCV E2 glycoprotein contains conserved basic residues in different regions.
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Abstract
<p>(A) Scheme of E2 putative GAG-binding sites and other regions important for entry and for proper protein folding. Amino acid numbers refer to positions in the polyprotein sequence of the H77 prototype isolate. N: glycosylation sites, HVR1, 2, 3: hyper-variable region 1, 2, 3, TM: transmembrane domain. (B) Frequency of basic residues at the positions analyzed in this study. The height of the box in each bar indicates the frequency of histidine (H, white box), lysine (K, light grey box) and arginine (R, dark grey box). The frequency of the basic residues at each position was calculated by dividing the number of basic residues by the total number of sequences (2073 sequences) and is expressed as a percentage.</p