Abstract

<p>10% w/v brain homogenates (n = 3 per group) were digested with proteinase K and immunoblotted with anti-PrP monoclonal antibody ICSM35 (D-Gen Ltd, UK). (A) Transmission of Chandler/RML prions to <i>Sod1<sup>−/−</sup></i> and <i>Sod1<sup>+/+</sup></i> (WT) litter mate controls. (B) Transmission of ME7 prion strain to <i>Sod1<sup>−/−</sup></i> and <i>Sod1<sup>+/+</sup></i> (WT) litter mate controls. (C) Transmission of MRC2 mouse adapted BSE prion strain to <i>Sod1<sup>−/−</sup></i> and <i>Sod1<sup>+/+</sup></i> (WT) litter mate controls. No differences were seen between the two groups regardless of prion strain.</p

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