<p>Genomic location is given based on mouse genome assembly NCBI build 37. Details of the <i>Sod1</i> and <i>Il1-r1</i> SNPs are available from the Sanger Centre (<a href="http://www.sanger.ac.uk/cgi-bin/modelorgs/mousegenomes/snps.pl" target="_blank">www.sanger.ac.uk/cgi-bin/modelorgs/mousegenomes/snps.pl</a>). All polymorphisms were analysed by allele discrimination using a 7500 Fast real time PCR system (Applied Biosystems). For probe details see Table S1. For all genotypes, the statistical test used was the Kruskal-Wallis non-parametric ANOVA. The allelic test used was the Mann-Whitney test.</p

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