Thrombosis develops in mutant mice during the second postnatal month.

Abstract

<p>(A) Ultrasound analysis of a <i>Tyr::Cre</i>; <i>ctnnb1Δex3</i>/+ ( =  ctnnb1Δex3) mouse with dilated left atrium containing a thrombus. (B) Isolated thrombus. Expansion of the left atrium is observed prior to the appearance of thrombosis in such ctnnb1Δex3 mice: (C) at 6 weeks of age and (D) at 8 weeks, from the same animal. <i>In situ</i> thrombus located in a ctnnb1Δex3 left atrium prior to (E) and after dissection (F). Thr: (thrombus), LA: (left atrium), LV: (left ventricle) and Lu: (lung). Scale bar, B = 1 mm.</p