Actual invadopodia formation of A549 cells in control group (A), EGF group (B), and GM6001/EGF group (C) in 3D extracellular matrix in the microfluidic device with confocal system.

Abstract

<p>Invadopodia could be obviously induced by EGF in (B), <b>while</b> this induction could be inhibited by GM6001 in (C). White arrowheads represented invadopodia. Magnification: ×1200.</p