<p>Comparison of E17.5 wild type and <i>Scube3<sup>−/−</sup></i> skeletal structures differentially stained for bone (alizarin red) and cartilage (alcian blue). (A, B) Gross appearance of the skeleton, including sternum and forelimb; (C, D) Skull, including lateral view (norma lateralis, left panels), cranial base (norma basalis, middle panels; note, the mandible has been removed), cranial vault (norma verticalis, right panels; note, the cranial base and nasal bones have been removed); (E) Mandible (lateral view); (F) Middle ear skeletal elements (right ear in wild type; left ear in mutant). ab, alveolar bone of mandible; agp, angular process of mandible; au, autopod; bb, basal bone of mandible; bm, body of malleus; bo, basioccipital; bs, basisphenoid; cdp, condylar process of mandible; cli, crus longus of incus; cna, cupola nasi anterior; crp, coronoid process of mandible; cs, coronal suture; eo, exoccipital; fpmx, frontal process of maxilla; fr, frontal; go, gonial; hu, humerus; in, incus; ip, interparietal; jg, jugal; li, lower incisor; lo, lamina obturans; ma, mandible; MC, Meckel's cartilage; mm, manubrium of malleus; mx, maxilla; na, nasal; ns, nasal septum; pbm, processus brevis of malleus; pca, pars canalicularis; pbm, processus brevis of malleus; pco, pars cochlearis; pl, palatine; pmx, premaxilla; pp, parietal plate; ppmx, palatine process of maxilla; pppl, palatine process of palatine; pppx, palatal process of premaxilla; pr, parietal; ptg, pterygoid; ra, radius; sc, scapula; so, supraoccipital; sq, squamosal; st, stapes; tr, tympanic ring; ui, upper incisor; ul, ulna; vm, vomer; zpsq, zygomatic process squamosal.</p
