Hedgehog signaling in wild type and <i>Scube3^−/−</i> mice.

Abstract

<p>Comparison of <i>Ptch1</i> expression in the developing craniofacial region of wild type and <i>Scube3^−/−</i> mice at E14.5 assayed by <i>in situ</i> hybridization on frontal sections. (A–D) Wild type; (G–H) <i>Scube3^−/−</i>. Orientation is through the primary palate (A, E), central region (B, F) and posterior region (C, G) of the secondary palate. Red square in B, F highlights <i>Ptch1</i> expression in the cap stage maxillary molar teeth shown in D, H (red hatched line outlines the enamel organ).</p