Relationship between cell proliferation in culture and number of tumor cells containing four-fold DNA amount.

Abstract

<p>(A) Inverse relationship (r²>0.95) in U87MG, FEMX-I, MDA-MB-231, and MA11 cell lines, between the number of cells in the G0/G1 peak and that of cells carrying four-fold DNA amount, as quantitated in cultures of each cell line by flow cytometric analysis for content of DNA; both cell populations are expressed as fractions over the total number of cells analysed from each culture. (B) Lack of correlation in cultures of fibroblasts (top panel), <i>vs.</i> negative correlation in cultures of U87MG glioma cells (bottom panel), between number of cells in the G0/G1 peak and number of cells carrying four-fold DNA amount.</p