<p>(A) Cells treated with cocaine and/or gp120 for 18 h were assayed for mitochondrial membrane potential by staining with JC-1 dye. Treatment with cocaine/gp120 resulted in reduction of the aggregation of JC-1 dye in the mitochondria (red fluorescence) and decreased ratio of the aggregate (red fluorescence) to monomer JC-1 (green fluorescence) in the cells. Scale bars indicate 200 µm. (B) Quantification of Δψm expressed as a ratio of J-aggregate to JC-1 monomer (red∶ green) fluorescence intensity. All the data are presented as mean±SD of three individual experiments. ** p<0.01; ***p<0.001 versus control group; #p< 0.05 versus cocaine group; ∧p< 0.05 versus gp120 group.</p
