SU5416 attenuates the deficit of locomotion behavior on zebrafish larval induced by MPTP.
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Abstract
<p>One dpf zebrafish embryos were treated with 200 µM MPTP for 2 days, and then co-incubated with 10 µM MPTP and SU5416 or VRI at the indicated concentrations for 72 hours, and zebrafish larval co-treated with MPTP and 150 µM L-dopa or 20 µM L-deprenyl were used as positive controls. After treatment, zebrafish were collected to perform locomotion behavior test using Viewpoint Zebrabox system and total distances travelled in 10 min were calculated. Data, expressed as percentage of control, were the mean ± SEM of 12 fish larvae per group from 3-time independent experiments. <sup>##</sup><i>p</i><0.01 <i>versus</i> control group; **<i>p</i><0.01 <i>versus</i> MPTP group (Turkey’s test).</p
