SU5416 reverses the elevated intracellular NO induced by MPP+ in CGNs.

Abstract

<p>CGNs were pre-incubated with EPTU, 7-NI or SU5416 at the indicated concentrations for 2 hours, and exposed to 35 µM MPP⁺. Intracellular NO level was measured using DAF-FM diacetate as a probe at 8 hour after MPP⁺ challenge. Data, expressed as percentage of control, were the mean ± SEM of three separate experiments; **<i>p</i><0.01 <i>versus</i> MPP⁺ group (ANOVA and Dunnett’s test).</p