Prenatal EtOH exposure changed the postnatal synaptic plasticity at corticalstratial pathway in the DL striatum.

Abstract

<p><b>A:</b> Synaptic plasticity in PD 15 control and EtOH offspring. The upper traces are the original PS waves at 15 min pre-HFS and 60 min post-HFS. Calibration bars: 0.3 mV and 4 msec. ‘↑’ indicates the time of HFS delivery. Note that HFS induced the significant potentiaton of the PS 60 min post-HFS indicative of LTP in control offspring, while did not change the PS amplitude 60 min post-HFS in EtOH offspring. <b>B&C:</b> Synaptic plasticity in PD 30–40 control and EtOH offspring. Note that HFS induced LTD in control offspring, but LTP in EtOH offspring.</p