Down-regulation of D2R leads to the shift of synaptic plasticity from LTD to LTP in PD 30 EtOH rats.

Abstract

<p>‘↑’ indicates the time point of HFS application. The hollow line represents the period of drug occurrence in ASCF. <b>A & B:</b> L-sulpiride completely blocked HFS induced LTD in control rats, but had no effect on HFS induced LTP in EtOH rats. <b>C:</b> the D2R agonist quinpirole recovered the induction of LTD in EtOH rats. <b>D & E:</b> SCH23390 completely blocked either the induction of LTD in control rats or quinpirole-recovered LTD in EtOH rats.</p