MicroRNA-126 inhibits cell invasion and tumor growth.

Abstract

<p>(A) Overe-xpression of microRNA-126 inhibits the cell invasion in A549 and SK-MES-1 cells. Compared with the control group, over-expression of microRNA-126 impaires cell invasion. (B) MicroRNA-126 impairs the cell proliferation in A549 and SK-MES-1 cells. The cell proliferation was dramatically decreased after cells were treated with microRNA-126 over-expression for 72 hours. (C) The tumor growth curve <i>in vivo</i> by intratumoral injection with microRNA-126. The growth of tumors was observed from 1 to 25 days after the last injection. (D) MicroRNA-126 inhibits growth of A549 cell and SK-MES-1 cells in vivo. The average tumor only about an half of the tumors weight in the mice treated with PBS or pE-CMV vector alone.</p

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