<p>Interacting atom distributions of compounds on (A) MDR and (B) WT NAs. The interacting atoms are shown as grids if interacting with the binding site by electrostatic (yellow), hydrogen-bonding (dark green), and van der Waals (gray) interactions. (C) Protein-compound interaction profiles. An entry is colored green if the screening compound yielded interactions with the residues; conversely, the entry color is black. The red frame shows the major difference of interaction preferences between WT and MDR NAs. (D) Interaction percentages of residues in the profiles.</p
