Plot of non-centrality parameter for the Bourgain test for a case-control study using two incompletely admixed populations as sources of cases and controls respectively.

Abstract

<p>The parameters chosen refer to a test of a variant associated with disease which has 40 percent overall allele frequency and which is associated with a 10 percent difference in frequency between cases and controls (OR = 1.5 per copy). Cases are assumed to have average admixture percentage of 20 percent and controls 25 percent. The within population heterogeneity is specified by a single common heterogeneity parameter as used in <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1001096#pgen-1001096-g001" target="_blank">Figure 1</a>.</p