Quercetin and allopurinol regulate renal urate transport-related proteins in streptozotocin (STZ)-treated rats.

Abstract

<p>Representative Western blot results (A) and graphic presentation showed renal protein expression of rOAT1 (B), rOAT3 (C), rUAT (D), rGLUT9 (E) and rRST (F) at 7 weeks after STZ injection in different groups of rats as indicated. The relative protein levels of rOAT1, rOAT3, rUAT and rGLUT9 were determined after normalization with rGAPDH. The relative BBMV rRST protein levels were normalized to rNa⁺-K⁺-ATPase. The data are expressed as the means ± SEM (n = 3–4). ⁺⁺<i>P</i><0.01, ⁺⁺⁺<i>P</i><0.001 <i>versus</i> normal control; *<i>P</i><0.05, **<i>P</i><0.01, ***<i>P</i><0.001 <i>versus</i> STZ control.</p