Abstract

<p><b>A) Spatio-temporal dipole and sLORETA source analysis of influences of </b><b><i>COMT</i></b><b> and </b><b><i>DAT1</i></b><b> polymorphisms on lateralized motor PINV</b>. <b>Left</b>: RAP-MUSIC spatial component model fitted on the motor PINV peak. For the homozygous 6R–10R/Met group (highest lateralized motor PINV amplitudes), spatial component #2 explained left lateralized motor PINV topography, while spatial component #1 eliminates additional activity related to the visual post-processing and the P300/late positive complex. In contrast, for the homozygous other/Val group low lateralized motor PINV amplitudes, no comparable activation could be found. <b>Middle</b>: Dipole moments for the homozygous 6R–10R/Met group (highest lateralized motor PINV amplitudes) compared to the homozygous other/Val group (low motor PINV amplitudes). Colours and numbers refer to the models presented on the left. The vertical dashed line indicates the time of the button press trigger. The interval of the motor PINV peak (400–600 ms after the response) is marked in orange. <b>Right</b>: sLORETA source analysis for the same two genetic groups. The location of spatial component #2 for the homozygous 6R–10R/Met group depicted on the left is indicated (coordinates x = −0.30, y = −0.12, z = 0.54). The crossing red lines were moved to the point where this dipole projects onto the cortical surface in order to illustrate the cortical activation which was explained by this spatial component. Note that there were two areas with a stronger lateralized activation for the homozygous 6R–10R/Met group, one located more frontally around Brodman areas 6 and 8 (red arrow, premotor cortex and frontal eye field); the other located more centro-parietally comprising Brodman areas 1–4 and 40 (blue arrow, motor, somatosensory and posterior parietal cortex). <b>B) Interaction between the </b><b><i>DAT1</i></b><b> haplotype and </b><b><i>COMT</i></b><b> for the lateralized motor PINV</b>. The error bars indicate the 95% confidence intervals.</p

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