Abstract

<p>MOC31-antibody binds to HT29 tumour cells <i>in vivo</i> after i.v. injection of 10 µg MOC31mAb in tumour bearing mice, as visualized with subsequent immunostaining against MOC31-antibody (red = MOC31 positive cells) in cryostat sections of the primary tumour. Controls using 10 µg IgG1 mAb confirmed the high specificity of MOC31 binding to tumour cells <i>in vivo</i>. The specific antibody MOC31 binding to the tumour cells was restricted to areas of the tumour, which were well supplied with blood vessels. Corresponding liver sections showed the intake of both antibodies by cells of the RES system.</p

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