Proposed model for reduced heart rate variability (HRV) in patients with major depressive disorder (MDD) and comorbid generalised anxiety disorder (GAD).

Abstract

<p>These patients typically experience worry and hypervigilance to threat, leading to a chronic withdrawal of the parasympathetic nervous system (PNS) and long-term reductions in HRV, placing these patients at an increased risk for cardiovascular disease (CVD) and sudden cardiac death (SCD).</p