Anti-sera against the hybrid vaccine show synergistic effects at low concentrations.
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Abstract
<p>The invasion inhibition of both combination sera are greater than those obtained from the individual sera at the lowest concentrations used, 1 µg/mL. The combinations contain 50% of each individual immunogen (in the case of the combination vaccination, anti-EBA-175<sub>RII</sub>/rRH5) or sera (in the case of the in-tube combination, anti-EBA-175<sub>RII</sub>+anti-rRH5). However, by 100 µg/mL, the synergistic effects of the combinations are no longer apparent, and the inhibition from the combinations is equivalent to ∼50% contribution from the two individual sera (anti-EBA-175<sub>RII</sub> shown by black bars, anti-rRH5 shown by blue bars, anti-EBA-175<sub>RII</sub>/rRH5 shown by red bars, anti-EBA-175<sub>RII</sub>+anti-rRH5 shown by green, control IgG shown by white bars).</p