MR appearance and volumes of lymph nodes various mouse strains.

Abstract

<p>(A) MR appearance of the axillary, brachial, inguinal and popliteal lymph nodes in C57Bl/6, Nude, CB-17 SCID and NOG mice. The brachial, inguinal and popliteal lymph nodes are easiest to visualize due to their location within a fat pad. Lymphatic vessels are also visible in acquired images (arrowhead). Images for the NOG mice are included for completeness although there were no MRI detectable lymph nodes. (B) Volumes of the axillary, brachial, inguinal and popliteal lymph nodes in C57Bl/6, Nude and CB-17 SCID mice. The brachial, inguinal and popliteal lymph nodes in CB-17 SCID mice were found to be significantly smaller than those in both C57Bl/6 and Nude mice (*, p<0.0001 for brachial and inguinal and p = 0.0128 for popliteal). The axillary node in Nude mice was significantly larger than those in both CB-17 SCID and C57Bl/6 mice (**, p<0.0001). One way ANOVA test was used. Error bars represent the standard deviation.</p