Characteristics of mitochondrial membrane potential (Δψ<sub>m</sub>) in human fibroblasts with PINK1 mutations.

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    <p>A-L2122 fibroblasts exhibited a 20% increase (p<0.001) in TMRM fluorescence (i,e, an increased Δψ<sub>m</sub>) compared to controls. Fibroblasts with PINK1 mutations (L2123, L2124, L2126 amd L1703) showed a significant decrease in Δψ<sub>m</sub> compared to control cells. B–G In control, L2122 and L2126 fibroblasts (B–C, F), oligomycin did not affect Δψ<sub>m</sub>; rotenone induced a partial depolarisation; FCCP induced complete depolarisation. In L2123, L2124 and L1703 fibroblasts (D–E, G), oligomycin caused a mitochondrial depolarisation.</p

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      Last time updated on 16/03/2018