<p>Compared to the highly structured GR’s DBD and LBD, the NTD/AF1 is mostly unstructured in solution (a). JDP2 interaction with the DBD/CTE transmits inter-domain signals to the AF1/NTD, resulting into secondary/tertiary structure formation in it (b). This induced structure in the AF1/NTD creates interaction surfaces for other coactivators (e.g., TBP and CBP) that mediate transcriptional activity of the AF1 (c). Undergoing conformational changes are indicated by different shapes and colors.</p
