Evaluation of combinatorial effects of drugs on reactivation and cellular signaling.

Abstract

<p>(A) Plot of the maximum achievable reactivation rates using combinations of two, three, four, and five drugs as predicted by the mathematical KSHV reactivation model. (B) A summary of the predicted interactions between the applied drugs and their effects of these interactions on KSHV reactivation. : Synergistic effect; : Inhibitory effect.</p