Risk of colon cancer according to baseline quintiles of one-carbon nutrient intake by CIMP expression in tumors among 88,691 women in the Nurses' Health Study (1980–2002).
‡<p>Age adjusted only.</p><p>*All models are adjusted for age (continuous), energy intake, gender, screening sigmoidoscopy, family history of colorectal cancer, aspirin use, smoking, physical activity in METs, baseline body mass index, a history of colon polyps, beef intake, calcium, multi-vitamin use, and baseline folate, vitamin B6, B12, methionine, and alcohol if not primary exposure. P for heterogeneity of the association for folate intake and CIMP-low/0 colon cancer versus folate intake and CIMP-high colon cancers = 0.73 (χ<sup>2</sup> = 1.31, 3 d.f.).</p><p>P for heterogeneity of the association for vitamin B<sub>6</sub> intake and CIMP-high colon cancer and vitamin B<sub>6</sub> intake and CIMP-low/0 colon cancers = 0.63 (χ<sup>2</sup> = 2.6, 4 d.f.) and for vitamin B<sub>12</sub> intake = 0.94 (χ<sup>2</sup> = 0.79, 4 d.f.). P for heterogeneity of the association for methionine intake and CIMP-high colon cancer and methionine intake and CIMP-low/0 colon cancers = 0.007 (χ<sup>2</sup> = 14.097, 4 d.f.), and for alcohol intake = 0.32 (χ<sup>2</sup> = 3.52, 3 d.f.).</p
