<p>Diagrammatic representation of the integrative relationship of the Gac/Rsm signal transduction pathway and the expressions of two <i>phz</i> clusters in <i>Pseudomonas</i> sp. M18. Less efficiency of expression of <i>phzA2-G2</i> gene cluster produce a small amount of PCA signal molecule to auto-induce transcriptional activity itself and the expression of <i>phzA1-G1</i> gene cluster (red fine lines). The high efficiency expression of <i>phzA1-G1</i> at transcriptional level were blocked by its 5′-UTR region and could be relieved partial in post-transcriptional level by PCA or some unknown factor(s) (red thick lines). The interactions of induction and self-induced among two <i>phz</i> clusters resulted in a large amount of PCA production as antibiotics for bio-control. The <i>phzA2-G2</i> expression was negatively controlled mainly at the post-transcriptional level by regulator GacA in respond to environmental signals at overall level. Symbols: solid circle, inhibition; solid arrow, activation; diamond, environmental signals; X, unknown factor(s).</p
