A model of persistent matrikine production and neutrophilic inflammation.

Abstract

<p>During chronic PMN inflammation, collagen is hydrolyzed releasing Ac-PGP causing ongoing neutrophilic influx (<b>A</b>). In addition to causing PMN influx, Ac-PGP ligation of CXCR1 and CXCR2 leads to intracellular ERK phosphorylation and activation (<b>B</b>) and degranulation of MMP-9 from PMN tertiary granules (<b>C and D</b>). This MMP-9 acts on exposed collagen leading to Ac-PGP generation (<b>E</b>) and a feed-forward inflammatory response on PMNs (<b>F</b>).</p