The IC₅₀ values of anti-V3 mAbs against 57 HIV-1 pseudoviruses tested using the U87 target cell line.

Abstract

<p>The IC₅₀ values were estimated from the titration curves of all mAb/psV combinations and are highlighted according to the color-coded scale. Pseudoviruses expressing Envs of JRCSF, NL3.4, and SF162 were tested as positive controls, whereas the irrelevant anti-parvovirus mAb 860 and aMLV Env-expressing psV were used as negative controls. When 50% neutralization was not achieved at the highest mAb concentration tested (50 µg/ml), the IC₅₀ values are shown as >50.</p