Impact of bisphenol A (BPA) on insulin-like growth factors (IGFs) and their receptors gene expressions.

Abstract

<p>Temporal changes in IGF-1 (A) and IGF-2 (B) and IGF-1 receptor a (IGF-1 Ra; C) and b (IGF-I Rb; D) mRNA abundances in rainbow trout embryos in response to BPA treatment. See the <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0010741#pone-0010741-g002" target="_blank">Fig. 2</a> legend for experimental details. Maternal transcript levels were measured in freshly fertilized eggs and represented as 0-dpf (dark colored bar). Two-way ANOVA was used to determine the effect of time, treatment and interaction effects on the transcript levels during development (Bonferonni post hoc test; p<0.05). Different letters represent differences between treatments at each time point. Asterisk (*) represent effect of time on mRNA abundances. All values represent mean + SEM (nβ€Š=β€Š7).</p

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