<p><b>A.</b> Among the genes upregulated in the long-lived mitochondrial mutant strains <i>clk-1</i>, <i>isp-1</i> and <i>nuo-6</i>, many of these genes (46%, 50% and 57% respectively) are also upregulated in <i>daf-2</i> mutants. <b>B.</b> A heat map showing the top DAF-16 responsive genes that are upregulated in <i>daf-2</i> mutants (genes included are from the meta-analysis of DAF-16 target genes performed by Tepper <i>et al</i>., 2013 that were significantly upregulated in our <i>daf-2</i> RNAseq data). Many of these genes are also upregulated in the long-lived mitochondrial mutant strains. mRNA for all strains was isolated from six biological replicates per strain and sequenced individually.</p
