Compatible Solute Binding to an Archaeal Inositol Monophosphatase

Abstract

Thesis advisor: Mary F. RobertsCrystallization studies in presence of organic osmolytes were conducted to better understand the specific mechanism of compatible solute binding to the inositol monophosphatase of Archaeoglobus fulgidus. The synthesis of a-diglycerol phosphate, one of the natural osmolytes of A. fulgidus, was also completed for kinetic testing of its I-1-Pase thermoprotective properties and for crystallization trials.Thesis (MS) — Boston College, 2011.Submitted to: Boston College. Graduate School of Arts and Sciences.Discipline: Chemistry

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